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[영문] 58호 (2017. 6. 19)
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Publication of report on R&D trend of genome engineering technologies
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The Ministry of Food and Drug Safety published a report on R&D trend of engineered nuclease technology in which the current development state and regulation related to the technology at the country level.

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Genome engineering technology enables the treatment of various incurable diseases fundamentally by editing or modulating genomes for removal of problematic genes or restoration to normal function.

Genome engineering technology will be applied not only to genetic diseases but also to various diseases including cancer, infectious disease, metabolic disorders and autoimmune disease.

Fig 1. Applications of Genome Engineering
(Reference: CMI Development and Application of CRISPR-Cas9 for Genome Engineering, Cell (2014))
Table 1. Current State of CRISPR-Cas9 Application
Industry sector Product/application Company
Food

Yogurt,Cheese
Crops

Danisco (DuPont)
Dow Agrosciences

Livestock
Crops

Recombinetics
Cellectis Plant Sciences

Laboratory

Research tools
Expression systems
Research tools
Animal models
Research tools
Anmal models

System Biosciences
Sigma-Aldrich
GE Healthcare
Sage
ThermoFisher
Taconic

Sublicensing

Ag, Industrial, Bio

Caribou

Medical

Pharmaceuticals
In vitro applications only
Target validation
Therapeutics
Monogenic diseases

Novartis
Cellectis
AstraZeneca
Crispr Therapeutics
Sangamo Biosciences

Therapeutics
Therapeutics
Intellia
Editas
(Reference: History and market impact on CIRSPR RNA-guided nucleases, ScienceDirect (2015))
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The report is expected to contribute to the development of treatment and commercialization of product using genome engineering technology in a preemptive manner for people in relevant industries including researchers, developers, and reviewers.
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Major contents

- Overview of Genome Engineering Technology

- Current R&D Status of Genome Engineering Technology on patent, non-clinical research and clinical research

- Related Regulations by country

Fore more details, visit the website of MFDS.

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