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߼ Ǵ ̼ ΰ 1 ġμ Pembrolizumab + Epacadostat, Pembrolizumab ܵ, ׸ EXTREME ȿ ϱ 3, , - ӻ (KEYNOTE-669/ECHO-304)

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Drug name Active Ingredients Submission Classification Company Approval date
Vyzulta (latanoprostene bunod ophthalmic solution), 0.024% NDA #207795 LATANOPROSTENE BUNOD Ź BAUSCH AND LOMB INC 11/02/2017
BORTEZOMIB
NDA #205004
BORTEZOMIB Ǵ FRESENIUS KABI USA 11/06/2017
PREVYMIS
NDA #209939
LETERMOVIR Ź MERCK SHARP DOHME 11/08/2017
Cinvanti (aprepitant) injectable emulsion NDA #209296 APREPITANT ſ뷮 HERON THERAPS INC 11/09/2017
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NCT Number Title Conditions Interventions Sponsor
Collaborators
Phases
NCT03339921 Botulinum for Chronic Exertional Compartment Syndrome Chronic Exertional Compartment Syndrome Drug: Botulinum toxin injections for chronic compartment syndrome|Procedure: surgical fasciotomy for chronic compartment syndrome 375th Medical Group,
Scott Air Force Base
Phase 2
Phase 3
NCT03338959 Pembrolizumab and Radiation Therapy in Treating Patients With Intermediate or High-Grade Soft Tissue Sarcoma Soft Tissue Sarcoma Biological: Pembrolizumab|Radiation: Radiation Therapy Fred Hutchinson Cancer Research Center
National Cancer Institute (NCI)
Phase 1
Phase 2
NCT03333590 Gene Transfer Clinical Trial to Deliver rAAVrh74.MCK.GALGT2 for Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Biological: rAAVrh74.MCK.GALGT2 Kevin Flanigan
Nationwide Children's Hospital
Phase 1
Phase 2
NCT03340558 Atezolizumab Monotherapy vs Atezolizumab Plus Cobimetinib in Liver Metastases From Colorectal Cancer Metastatic Colorectal Cancer Biological: Atezolizumab|Drug: Cobimetinib Niharika Mettu
Genentech/Roche
Duke University
Phase 2
NCT03339713 A Study to Evaluate the Safety and Immunogenicity of Seasonal Influenza Vaccine and an Adenovirus Serotype 26- Based Vaccine Encoding for the Respiratory Syncytial Virus Pre-fusion F Protein (Ad26.RSV.preF), With and Without Co-administration, in Adults Aged 60 Years and Older in Stable Health Healthy Biological: Ad26.RSV.preF|Biological: Fluarix|Biological: Placebo Janssen Vaccines & Prevention B.V. Phase 2
NCT03338972 Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma|TNFRSF17 Positive Biological: BCMA-specific CAR-expressing T Lymphocytes|Drug: Cyclophosphamide|Drug: Fludarabine|Other: Laboratory Biomarker Analysis|Procedure: Leukapheresis Fred Hutchinson Cancer Research Center
Juno Therapeutics, Inc.
National Cancer Institute (NCI)
Phase 1
NCT03337542 AR101 Real-World Open-Label Extension Study Peanut Allergy Biological: AR101 Aimmune Therapeutics, Inc. Phase 3
NCT03333616 Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary Tumors Genitourinary Cancer|Adrenocortical Carcinoma|Non-urothelial Bladder|Non-urothelial Upper Tract|Penile Cancer|Non-adenocarcinoma Prostate Cancer|Refractory Germ-cell Drug: Ipilimumab|Drug: Nivolumab Dana-Farber Cancer Institute
Bristol-Myers Squibb
Phase 2
NCT03336333 A Study Comparing BGB-3111 With Bendamustine Plus Rituximab in Patients With Previously Untreated CLL or SLL Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma Drug: BGB-3111|Drug: Bendamustine|Drug: Rituximab BeiGene Phase 3
NCT03336216 A Study of Cabiralizumab Given With Nivolumab With and Without Chemotherapy in Patients With Advanced Pancreatic Cancer Advanced Pancreatic Cancer Biological: Cabiralizumab|Drug: Nab-paclitaxel|Drug: Onivyde|Biological: Nivolumab|Drug: Fluorouracil|Drug: Gemcitabine|Drug: Oxaliplatin|Drug: Leucovorin Bristol-Myers Squibb Phase 2
NCT03337698 A Study Evaluating The Efficacy And Safety Of Multiple Immunotherapy-Based Treatment Combinations In Patients With Metastatic Non-Small Cell Lung Cancer Carcinoma, Non-Small-Cell Lung Drug: Atezolizumab|Drug: Cobimetinib|Drug: RO6958688|Drug: Docetaxel|Drug: BL-8040|Drug: Tazemetostat|Drug: CPI-444|Drug: Pemetrexed|Drug: Carboplatin|Drug: Gemcitabine Hoffmann-La Roche Phase 1
Phase 2
NCT03338790 An Investigational Immunotherapy Study of Nivolumab in Combination With Rucaparib, Docetaxel, or Enzalutamide in Metastatic Castration-resistant Prostate Cancer Prostate Cancer Biological: Nivolumab|Drug: Docetaxel|Drug: Enzalutamide|Drug: Rucaparib|Drug: Prednisone Bristol-Myers Squibb
Clovis Oncology
Astellas Pharma Inc
Phase 2
NCT03337477 A Study to Evaluate a Potassium Normalization Treatment Regimen Including Sodium Zirconium Cyclosilicate (ZS) Among Patients With S-K 6.0 . Hyperkalemia Drug: Placebo|Drug: Sodium Zirconium Cyclosilicate(ZS)|Drug: Insulin|Drug: Glucose AstraZeneca Phase 2
NCT03334617 Phase II Umbrella Study of Novel Anti-cancer Agents in Patients With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy. Non-Small Cell Lung Cancer Drug: Durvalumab|Drug: AZD9150|Drug: AZD6738|Drug: Vistusertib|Drug: Olaparib AstraZeneca Phase 2
NCT Number Title Conditions Interventions Sponsor
Collaborators
Phases
NCT03334656 Controlled and Double Blind Comparison of a Traditional Dressing Versus a Biologic Dressing Composed of Fetal Fibroblasts and Keratinocytes in Association With a Collagen Matrix on Skin Donor Sites Split Thickness Skin Graft|Wound Healing Biological: biological dressing|Other: Paraffin gauze dressing Nantes University Hospital Phase 1
Phase 2
NCT03334695 An Exploratory Study to Evaluate the Prophylactic Efficacy of a Single Immunization of Ad26.RSV.preF Against Respiratory Syncytial Virus Infection in a Virus Challenge Model in Healthy 18 to 50 Year-old Adults Healthy Biological: Ad26.RSV.preF|Drug: Placebo Janssen Vaccines & Prevention B.V. Phase 2
NCT03339661 Secondary Prophylaxis After CMV Disease in Kidney Transplant Patients Targeted by T Cells Immunomonitoring. Kidney Transplant Infection Drug: Group 1_No proph treatment|Drug: Group 2A_Proph treatment and T cell expansion|Drug: Group 2B_Proph treatment and no T cell expansion University Hospital, Bordeaux Phase 2
NCT03339973 Allogeneic ABCB5-positive Stem Cells for Treatment of PAOD Peripheral Arterial Occlusive Disease Biological: allo-APZ2-PAOD|Drug: Placebo RHEACELL GmbH & Co. KG
FGK Clinical Research GmbH
TICEBA GmbH
Granzer Regulatory Consulting & Services
Phase 1
Phase 2
NCT03337698 A Study Evaluating The Efficacy And Safety Of Multiple Immunotherapy-Based Treatment Combinations In Patients With Metastatic Non-Small Cell Lung Cancer Carcinoma, Non-Small-Cell Lung Drug: Atezolizumab|Drug: Cobimetinib|Drug: RO6958688|Drug: Docetaxel|Drug: BL-8040|Drug: Tazemetostat|Drug: CPI-444|Drug: Pemetrexed|Drug: Carboplatin|Drug: Gemcitabine Hoffmann-La Roche Phase 1
Phase 2
,
NCT03338790 An Investigational Immunotherapy Study of Nivolumab in Combination With Rucaparib, Docetaxel, or Enzalutamide in Metastatic Castration-resistant Prostate Cancer Prostate Cancer Biological: Nivolumab|Drug: Docetaxel|Drug: Enzalutamide|Drug: Rucaparib|Drug: Prednisone Bristol-Myers Squibb
Clovis Oncology
Astellas Pharma Inc
Phase 2
NCT03334617 Phase II Umbrella Study of Novel Anti-cancer Agents in Patients With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy. Non-Small Cell Lung Cancer Drug: Durvalumab|Drug: AZD9150|Drug: AZD6738|Drug: Vistusertib|Drug: Olaparib AstraZeneca Phase 2
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